How Does Profhilo® work?

Profhilo is the first BDDE-free injectable Hyaluronic Acid for hydrating skin and treating skin laxity. With one of the highest concentrations of HA in the market (64mg/2cc), the stabilised HA lasts in the skin for about 28 days. Profhilo works because of 2 types of hyaluronic acid: L-HA and H-HA. This hybrid of HA allows hyaluronic acid to be released slowly and lasts longer allowing bio remodelling to take place. L-HA as a hybrid complex is released slowly and hydrates your skin, providing the Hydro effect. H-HA provides a stable HA architecture in the dermis that allows volumetric replacement, giving the Lift effect. During this time, the slow release of HA kickstarts stimulation of 4 different types of collagen and elastin. Histologically, the expression levels of type I and type III collagen and type IV and VII collagen in keratinocytes are increased.

How is Profhilo® different from other HA fillers?

A new thermal cross-linking method called the NAHYCO TECHNOLOGY™ modifies the characteristics of the two weights of Hyaluronic Acid (HA) which goes on to remodel the skin tissues. This technique is commonly utilised in bio revitalisation treatments. As a result of this technology, there is a longer-lasting time release of the two HA molecules. This double action is perfect for redesigning skin laxity. 


The first of its kind in Singapore aesthetics industry, Profhilo® is a revolutionary bio-remodelling and anti-ageing treatment. It is a tissue modulator that hydrates your skin from within and boosts the production of new collagen and elastin for dewy, full-volume, glowing and healthy-looking skin that lasts for months. To top it off, Profhilo® also stimulates four types of collagen and elastin, while simultaneously increasing adipocytes (fat) stem cells — this means tighter skin and enhanced defence against the signs of ageing.

Depending on the skin condition and type, you can see the effect after 1-3 treatments. For best results, we recommend 3 sessions at an interval of 3 weeks.

L-HA is time-released and deeply hydrates your skin, H-HA provides a dermal scaffolding in the dermis that holds up and lifts the contours of your face. Profhilo® lasts around 28 days in the skin. Within that time, there is the stimulation of 4 different types of collagen and elastin in multiple skin layers that takes place by slow release of HA.

Profhilo® is not a dermal filler or skin revitaliser. It is in-between a skin booster and a filler, occupying a brand-new created injectable classification called Bio-remodelling. 



Depending on where Profhilo® is injected (face, neck, inner arms and/or hands), it stimulates the production of elastin, collagen and boosts hydration in the skin, bringing about:
⦁ Softening and reduction of lines
⦁ Increased skin tautness
⦁ Healthier-looking skin
⦁ More youthful skin
Visible improvements in skin quality and hydration are observed in as early as 4 weeks after treatment and continue to do so in the ensuing months. Effects last between 6 – 12 months.

The face is cleansed and anaesthetic cream is applied onto the 5 Bio-Aesthetic Points (BAP) on each side of the face. The BAP represents the injection sites of Profhilo®, carefully selected to keep risks to vessels and nerves to a minimum. Once injected, Profhilo® immediately starts to spread throughout the face.
This procedure is performed by our doctors who are registered with the Singapore Medical Council.

The initial bumps observed at each injection site rapidly subsides in the next few hours. There is virtually no downtime for this treatment.

Doctor’s recommendation

For the best outcomes, we recommend that you have 3 treatment sessions, 1 month apart.
Profhilo® delivers great results as a treatment on its own or in combination with other aesthetic treatments