Profhilo vs Rejuran Healer: Difference Between Rejuran and Profhilo

Human skin starts to gradually lose smoothness, elasticity, and hydration with age. It happens due to the gradual reduction of collagen and elastin production. Therefore, the older we get, the more necessary it becomes to take proper care of your skin

There are many treatments on the market designed to combat aging skin. Among them, injectables are one of the most common ones. However, there are so many options available that many are often spoilt for choice.

To help you make a decision, we will look at 2 of the commonly known anti-aging injectables on the market: Rejuran and Profhilo, and compare them to help you make an informed decision.

These 2 treatments are similar in a few ways, and to the layperson, it is also these similarities that confuse us to think that they are the same.

So, what exactly does Profhilo do? And what is Rejuran? What are the main similarities and differences between rejuran and profhilo? And, finally, how to choose between these two products? Go through the below-mentioned text to find answers to these questions. Let’s start the Profhilo vs. Rejuran battle right away!


Profhilo is a brand of cosmetic injectables that produces solutions indicated for overall skin repair. It is manufactured in Switzerland by IBSA Group.

The composition of Profhilo is based on pure thermally cross-linked hyaluronic acid (HA). More precisely, it combines both high-molecular-weight HA and low-molecular-weight HA. The technology that is employed by Profhilo to create a hyaluronic acid-based solution is called NAHYCO. It ensures high safety, effectiveness, and long-lasting duration of the product.

Profhilo belongs to skin boosters that effectively treat sagging, dehydrated, and dull skin. Among the main areas that might be treated by Profhilo are the face, neck, decolletage, arms, and hands.

According to its treatment course, Profhilo should be injected beneath a patient’s skin during the two procedures with a four-week interval between them. The complete Profhilo treatment usually provides a patient with a six-months result that might be prolonged by multiple injections from time to time.

Due to the high concentration of hyaluronic acid, profhilo disperses quickly underneath the skin’s surface and instantly reacts with your own tissue to boost hydration. The most common area people choose to have Profhilo is the face. However, you can also use the treatment on your arms, hands, neck, knees, and chest. 

An Overview of Profhilo
Treatment Duration 15 minutes
Recommended Sessions 2-3 sessions
Recommended Interval 2-3 sessions 1 month apart, then 6-monthly maintenance thereafter
Recovery Time Minimal



Rejuran, in its turn, is also a brand of cosmetic injectables that specializes in the production of injectable skincare products.

It is manufactured in South Korea by PharmaResearch. Among a number of injectable products in the Rejuran family, Rejuran Healer is considered to be the most popular one.

The composition of injectable Rejuran Healer treatments is based on polynucleotide (PN). Interestingly enough, it is a biological substance produced from salmon DNA fragments (which is, by the way, very similar to human DNA).

When injected into skin, PN molecules increase cellular activity, enhance collagen synthesis, and reduce inflammation, helping to heal damaged skin and repair signs of ageing.

Rejuran Healer enhances collagen production, improves skin elasticity, and firmness, and reduces the appearance of fine lines and wrinkles. It is made with polynucleotide (PN), a powerful compound that has been shown to stimulate collagen production and accelerate the skin's natural healing process.

Other benefits of Rejuran Healer (and why it’s so popular), include reduction of the appearance of acne scars through collagen production and increased skin hydration. Rejuran Healer is especially suitable for sensitive and damaged skin because of its natural healing properties. Latest, all you need to know about Rejuran Healer here.

An Overview of Rejuran Skin Booster
Treatment Duration 30 minutes
Recommended Sessions 3-4 sessions
Recommended Interval Monthly initially for 3 sessions, then 6-monthly maintenance thereafter
Recovery Time 3 Days


Profhilo and Rejuran are in many ways similar. The main resemblances between these products include:

  • Both brands produce injectable aesthetic procedures that effectively reduce fine lines, make sagging skin more elastic, and fight skin dryness;
  • Profhilo and Rejuran are injectable moisturizers that effectively fight dry skin;
  • The average duration of Profhilo and Rejuran results is roughly equal (depending on the patient’s unique skin properties, it might last up to six months);
  • Similar to Profhilo injections, the administration of Rejuran is minimally invasive and should be performed in a series of multiple micro-injections;
  • Both treatments play an active role when it comes to collagen synthesis. Therefore, they improve overall skin health;
  • Just like Profhilo, Rejuran is well-compatible with the numbing cream (it is usually applied by a healthcare provider before the procedure to reduce a patient’s feeling of pain or discomfort);
  • Neither Profhilo nor Rejuran belong to dermal fillers.
  • They are all injectable treatments, usually delivered in the form of multiple injections on the skin of the face either manually or with an injector. 
  • They do not change the shape of our faces. 
  • Profhilo Singapore contains hyaluronic acid (HA) like dermal fillers, but due to structural differences, they do not add to volume in the face. Compared to Rejuran, Profhilo is able to stimulate both collagen and elastin at multiple layers of the skin. Rejuran Healer is better suited to stimulating only collagen (without elastin) in the superficial (upper) layer of the skin.


Difference between Rejuran and Profhilo as follows:

When it comes to skin rejuvenation treatments, two popular options that often come up are Profhilo and Rejuran. While both treatments aim to improve the overall appearance of the skin, there are some key differences between the two as follows:

  • One of the key dissimilarities between Profhilo and Rejuran is the fact that they are based on different active substances. Namely, Profhilo employs pure hyaluronic acid. While Rejuran, in its turn, is based on polynucleotide. Despite the fact that both substances are fully biocompatible, safe, and effective, they have absolutely different natures, properties, and working principles;
  • Rejuran primarily deals with the superficial layer of the skin. While Profhilo, in its turn, has an impact on multiple layers of the skin tissue;
  • Profhilo is usually administered within two procedures. While Rejuran, in its turn, requires three to four procedures to start working;
  • Unlike Rejuran, Profhilo might not be suitable for the activation of collagen production and overall rejuvenation of thinner skin;
  • The administration of Profhilo usually requires five strategic injections using the bio aesthetic points (BAP) technique. While Rejuran, in its turn, demands multiple strategic injections with the help of an injection gun;
  • The main function of Profhilo is skin hydration. However, Rejuran does the best job when it comes to the treatment of open pores and depressed acne scars;
  • The downtime required by Rejuran is minimal and equals two days. At the same time, however, Profhilo does not require any downtime at all;
  • Profhilo is not indicated for the treatment of delicate areas, such as the nose, upper lip, or certain zones around the middle and lower face. While Rejuran, in its turn, might be applied to practically any area of the face and body (including the delicate periorbital zone to reduce dark eye circles;


PROFHILO Hyaluronic acid Increased skin hydration and stimulates collagen and elastin production Face, neck, under-eye, decolletage and hands
REJURAN HEALER Polynucleotide (PN) Enhances collagen production, improves skin elasticity and firmness Face, neck, under-eye area and hands


Can I Do Rejuran and Profhilo Together?

Yes, Rejuran and Profhilo can be done together as they work synergistically
. If you are interested in a holistic Rejuran treatment and Profhilo treatment combination treatment plan, please contact your aesthetic doctor for more information.

Benefits of Profhilo and Rejuran as follows:

Benefits of Profhilo:

  • Profhilo is the first revolutionary bio-remodeling “injectable skincare” that addresses skin laxity and signs of aging through the bio-stimulation of collagen, elastin, and adipocytes stem cells that were lost through skin aging.
  • Profhilo had high hyaluronic concentration using 32mg of high molecular weight HA and 32mg of low molecular weight HA.
  • Profhilo is not a filler or a skin booster, Profhilo regenerates new tissue and cells, leading to a new skin architecture without volumization.
  • Profhilo wakes up dormant fibroblast to allow it to regenerate collagen, and elastin, and complement the results of the skin booster.
  • Profhilo works on multiple layers of the skin, and multilevel 3D flowability.
  • Profhilo has been clinically proven for safety, efficacy, and bio-compatibility.
  • Profhilo uses a unique BAP (Bio Aesthetic Points) injection technique for optimal diffusion of the product. With just 5 BAP injection point per side of the face, Profhilo diffuses through the different skin layers, across the face through, bringing a natural and lasting refreshed look.
  • Minimal pain and downtime.

Benefits of Rejuran:

  • Rejuran Healer treatment is a revolutionary skincare procedure that has taken the beauty industry by storm. This innovative treatment harnesses the power of salmon DNA to rejuvenate and heal the skin, delivering remarkable results that will leave you looking and feeling your best.
  • One of the key benefits of Rejuran Healer treatment is its ability to stimulate collagen production. As we age, our skin naturally loses collagen, leading to the formation of fine lines, wrinkles, and sagging skin. However, with Rejuran Healer, you can turn back the clock and restore your skin’s youthful elasticity. The salmon DNA in the treatment acts as a powerful stimulant, prompting your skin to produce more collagen, resulting in a firmer, smoother complexion. Say goodbye to dull and tired-looking skin and hello to a radiant and youthful glow.


Well, the best option is to rely on your aesthetic doctors or your singapore dermatologist who will investigate the skin peculiarities of a patient and choose the most suitable treatment for you.

At the same time, however, here is the list of things that might make the choice between Profhilo and Rejuran easier:

  • If you have an allergy to hyaluronic acid (and, therefore, cannot undergo Profhilo injection), you might want to try out Rejuran injection to rejuvenate the skin;
  • You might also opt for Rejuran near me in case you have exceptionally thin and sensitive skin;
  • In case of not willing to undergo any downtime, the usage of Profhilo injection might be a more reasonable solution;
  • Choose Rejuran injection if your main aesthetic problems are large pores and acne skin. And vice versa, try out Profhilo injection if your primary concern is the dryness of the skin


It is not accurate to say that one treatment is better than the other because they are different treatments that work through different mechanisms and are used for different purposes.

Profhilo and Rejuran are both effective treatments for skin rejuvenation, but they target different aspects of skin aging.

Profhilo Singapore is primarily used to hydrate and lift the skin, while Rejuran Singapore is designed to stimulate collagen production and improve skin texture.

The choice between the two treatments will depend on the individual patient’s skin concerns and goals. A qualified and experienced aesthetic doctor singapore will be able to recommend the best treatment plan for each patient based on their specific needs.

It is important to note that both Profhilo and Rejuran near me are medical procedures that should only be performed by trained and qualified medical professionals. Patients should always consult with a licensed and experienced aesthetic doctor Singapore before undergoing any type of aesthetic treatment.


Difference between Rejuran and Profhilo Price Singapore as follows:

The cost of Profhilo in Singapore starts from $1000 per syringe (2cc) (excl gst), and $3000 for 4 sessions. Depending on your skin condition, more than one (1) Profhilo treatment session might be needed to achieve desired results. Result varies with individuals.

The cost of Rejuran Healer in Singapore can vary from clinic to clinic. However, you can expect it to cost around$650 to $1,400 per session.

Cost may vary accordingly depending on the individual’s needs and preferences. Result varies with individuals.


If you’re wondering if Rejuran Healer treatment is the solution to your specific skin concern, or Profhilo injection treatment is more suitable for your skin, or can you do Rejuran and Profhilo together, then it’s best to book a consultation with our team of aesthetic doctors. During your consultation we can examine your skin and get an understanding of what you’d like to achieve. With that information, we can then help you to make an informed and educated decision about the best treatment for you. 


Both men and women wanting to improve skin hydration and overall quality can try Profhilo Treatment. And while there are no age limits or restrictions, it is recommended for patients 30 and above. You may be a suitable candidate if you:

  • Are experiencing the first signs of aging or laxity
  • Notice a change in your skin texture like fine lines, a loss of elasticity, and some crepiness 
  • Look a bit older than your age
  • Notice that your skin lacks hydration
  • Want to achieve a beautiful, youthful glow
  • Your skin lost the radiance it once had

A consultation with an aesthetic doctor will determine if Profhilo treatment is right for you or if there are other treatments more suitable to the concerns you wish to treat or improve.

Yes, Profhilo treatment is safe. It does not contain any additives like BBDE, which is known to increase the formation of lumps. Just make sure to have the treatment administered by a trained and experienced medical practitioner. 

Side Effects of Profhilo are as follows:

  • some redness and swelling
  • slight bruising after the treatment,

but these are temporary and subside after a few hours. 

There is little to no downtime, but it is recommended to avoid intense workouts after the treatment. Patients are also advised to avoid anti-inflammatory medications and alcohol 24 hours before the procedure.

Yes, you can combine Profhilo with other treatments. Combining Profhilo with other treatments allows you to address a wider range of skin concerns that go beyond what Profhilo alone can cover. 

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